Nova™ IJM System
Experience unparalleled scalability with the Nova™ Platform—a groundbreaking modular system for lipid nanoparticle (LNP) production that redefines ease and efficiency.
Ease & Reliability: Simply save your protocols and easily produce nanoparticles (0.2 mL to >100 mL) of similar size (50-150nm), PDI (<0.2), and encapsulation efficiency (>90%).
Modularity: Elevate your capabilities by seamlessly integrating in-line dilution or additional mixer modules as you need them.
Reusability: No recurring chip costs. Enhance your research with sustainable, cost-effective solutions that streamline your workflow.
Scalability: Effortlessly increase production using the same mixing principles with the Nova™ Pilot High Throughput (HT) system. GMP and 21 CFR Part 11 compliant.
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Nova™ BT system with standard dual pump module and single-stage
impinged jet mixer (Nova™ IJM)
Nova™ Benchtop
Helix Biotech’s Nova™ Benchtop (BT) System is designed for lipid nanoparticle R&D and pre-clinical development – screen and optimize nanoparticle formulations quickly and with a versatile and scalable platform.
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The Nova™ BT is a flexible modular platform for lipid nanoparticle synthesis. Researchers can choose from a range of IJM mixers or utilize common and custom microfluidic chips while screening lipid compositions and optimizing RNA+LNP formulation process parameters affecting encapsulation, particle size and polydispersity, and stability.
Best For: Research and Development and lab-scale production.
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Mixing Technology Options:
- Helix Impinged Jet Mixers (IJMs)
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Polyether ether ketone (PEEK)
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Stainless Steel
- Microfluidic chip compatible
Modules Components
Pumps: Dual Pump Modules
Single Pump Modules
Mixing Modules
Sample Collection Modules
Software and Control
Custom User Interface
Monitor and control formulation
via PC or laptop.
Formulation Optimization - Common Easily Tunable Parameters
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TFR - Total Flow Rate
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FRR - Flow Rate Ratio
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Process Startup/End Wastes, Priming Volumes
The Nova™ Platform is a modular system which means that scaling up is as easy as adding modules (pump and/or mixer modules). Simply add a pump module and second mixing stage for in-line dilution or nanoparticle modification capabilities. For larger production capacity, blast through to the Nova Pilot High Throughput (HT) system.
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Nova™ BT system with optional modules
Scaleup Studies: Moving from ≤0.2mL to ≥100mL
The default Nova™ BT platform including a dual pump module, single-stage mixer, and sample collector can be used to prepare samples as small as 100uL while also enabling scaleup to ≥ 100mL per run. The system provides a repeatable manufacturing process, allowing pooling of multiple batches to produce ≥ 1L of material. All Nova™ BT processes and mixing technologies are designed to facilitate seamless tech transfer and process scaleup with SuperNova™ High Throughput (HT) systems.
See the Nova in Action!
