ALC-0315 LNP Mix, 35mM, 2mL (in Ethanol)
 
This contains a ready-to-use lipid nanoparticle (LNP) ethanolic mixture containing:
 
46.3% - ALC-0315 (Ionizable Cationic Amino Lipid)
9.4% - 1,2-distearoyl-sn-glycero-3-PC (1,2-DSPC, Phospholipid)
42.7% - Cholesterol
1.6% - ALC-0159 (Lipid Excipient)
 
The mix is pre-portioned in ethanol with all components at their proper ratios for immediate LNP synthesis.
 
A separate formulation buffer is included: 100 mM Sodium Acetate buffer at pH 5,
Commonly used for encapsulating mRNA because the slightly acidic pH stabilizes the ionizable lipid and promotes efficient particle formation.
 
This kit comes with a detailed protocol and formulation guidelines to help you quickly start creating and optimizing LNPs with ALC-0315 for your specific application.