Lipid nanoparticles have earned their place as the delivery platform of choice for RNA therapeutics. The COVID-19 vaccines proved they could work at global scale, and a growing pipeline of siRNA, mRNA, and gene editing therapies has validated their versatility. But there is a problem the field has been grappling with quietly for years: most LNPs, when administered systemically, end up in the liver. For hepatic indications, that's fine. For everything else, such as T cells, tu

When Should You Use a Standard LNP Composition versus a Custom Lipid/Polymer Formulation?

In recent conversations with clients, there's been a surge of interest around a rather intriguing subject in the biotech world: lipid nanoparticles (LNPs) and, specifically, the state-of-the-art mixing techniques used in their production. Clients do not know the difference between the turbulent mixing approach and that of microfluidics - they often come to us to enlighten them and explain which one is better! Over the years, our team has witnessed the evolution of numerous m

Nine elephant calves at the Houston, Fort Worth, Rosamond Gifford, and Cincinnati zoos, received a groundbreaking EEHV mRNA-LNP vaccine developed through the efforts between Baylor College of Medicine, Helix Biotech, Avanti Polar Lipids/Croda and partner zoos.

Lipid nanoparticles (LNPs) are composed of several types of lipids that have been identified and developed for enhanced drug delivery.

Lipid nanoparticles (LNPs) are an advanced non-viral drug delivery system composed of different types of lipids: 1) Ionizable cationic...