In recent conversations with clients, there's been a surge of interest around a rather intriguing subject in the biotech world: lipid nanoparticles (LNPs) and, specifically, the state-of-the-art mixing techniques used in their production. Clients do not know the difference between the turbulent mixing approach and that of microfluidics - they often come to us to enlighten them and explain which one is better! Over the years, our team has witnessed the evolution of numerous m

Lipid nanoparticles (LNPs) have become essential tools in delivering nucleic acids like mRNA and siRNA for vaccines and gene therapies. A critical but often overlooked aspect of LNP development is the choice of formulation buffers. These buffers influence particle stability, encapsulation efficiency, and ultimately, clinical success. This guide breaks down the common buffers used in LNP formulation and storage, highlights what commercial and clinical products use, and helps y